一、動物模型相關文獻薈萃分析
以“animal model”為關鍵詞，在Pubmed（https://pubmed.ncbi.nlm.nih.gov/）進行檢索，2022年共發表20,008篇文獻。
2. 萬方數據庫收錄的動物模型文獻
以“動物模型”為關鍵詞，在萬方數據庫（https://www.wanfangdata.com.cn/index.html?index=true）進行檢索，2022年共發表2177篇期刊論文。使用萬方數據庫提供的文獻檢索結果分析工具，對2022年“動物模型”相關中文文獻的關鍵詞、作者、機構、學科等分析，結果見圖1-5。
就文獻發表關鍵詞分布情況而言，相關的關鍵詞包括動物模型、大鼠、小鼠、氧化應激、動物實驗、網絡藥理學等（圖1）。
圖1萬方數據庫中“動物模型”相關中文文獻的關鍵詞分布情況
就文獻發表作者分布情況而言，發表動物模型相關文獻最高的學者包括王雅春、劉彥士等（圖2）。
圖2 萬方數據庫中“動物模型”相關中文文獻的作者分布情況
就文獻發表單位分布情況而言，發表動物模型相關文獻最多的單位包括中醫藥大學第一附屬醫院、中國農業大學、北京中醫藥大學、廣西中醫藥大學等（圖3）。
圖3 萬方數據庫中“動物模型”相關中文文獻的單位分布情況
就文獻發表學科分布情況而言，發表動物模型相關文獻最多的學科包括醫藥衛生、農業科學、生物科學、工業技術等（圖4）。
圖4 萬方數據庫中“動物模型”相關中文文獻的學科分布情況
就文獻發表雜志分布情況而言，發表動物模型相關文獻最多的雜志包括中國組織工程研究雜志、中國比較醫學雜志、動物營養學報、中國實驗動物學報等（圖5）。
圖5 萬方數據庫中“動物模型”相關中文文獻的學科分布情況
二、2022.4-2022.8 PubMed數據庫收錄的動物模型相關文獻
1.急性缺血性中風大型動物模型比較研究
參考文獻：Taha A, Bobi J, Dammers R, et al. Comparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use?. Stroke. 2022;53(4):1411-1422. doi:10.1161/STROKEAHA.121.0360502.從小鼠脾細胞中分離和擴增小鼠 γδT細胞參考文獻：Williams L, Dery KJ, Lee WH, Li H, Shively JE, Kujawski M. Isolation and expansion of murine γδT cells from mouse splenocytes. J Immunol Methods. 2022;508:113322. doi:10.1016/j.jim.2022.1133223.從新生小鼠到老年小鼠乳腺干細胞基因表達特征的演變 參考文獻：Huang X, Xu Y, Qian L, et al. Evolution of gene expression signature in mammary gland stem cells from neonatal to old mice. Cell Death Dis. 2022;13(4):335. Published 2022 Apr 12. doi:10.1038/s41419-022-04777-x4.小鼠和人類之間保守的年齡相關區域表觀遺傳特征研究參考文獻：Perez-Correa JF, Tharmapalan V, Geiger H, Wagner W. Epigenetic Clocks for Mice Based on Age-Associated Regions That are Conserved Between Mouse Strains and Human. Front Cell Dev Biol. 2022;10:902857. Published 2022 Jun 3. doi:10.3389/fcell.2022.9028575.年輕供體小鼠的糞便微生物群移植可改善老年小鼠的卵巢功能參考文獻：Xu L, Zhang Q, Dou X, et al. Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice [published online ahead of print, 2022 May 30]. J Genet Genomics. 2022;S1673-8527(22)00157-6. doi:10.1016/j.jgg.2022.05.006
6. Fancb缺乏導致小鼠卵巢早衰研究
參考文獻：Cen C, Chen J, Lin L, et al. Fancb deficiency causes premature ovarian insufficiency in mice† [published online ahead of print, 2022 May 20]. Biol Reprod. 2022;ioac103. doi:10.1093/biolre/ioac103
7. 壓力相關的恐懼記憶獲得障礙研究
參考文獻：Nascimento EB, Dierschnabel AL, Lima RH, et al. Stress-related impairment of fear memory acquisition and disruption of risk assessment behavior in female but not in male mice. Behav Processes. 2022;199:104660. doi:10.1016/j.beproc.2022.1046608.超聲介導的阿爾茨海默氏癥衰老小鼠中生物效應研究參考文獻：Balbi M, Blackmore DG, Padmanabhan P, Götz J. Ultrasound-Mediated Bioeffects in Senescent Mice and Alzheimer's Mouse Models. Brain Sci. 2022;12(6):775. Published 2022 Jun 13. doi:10.3390/brainsci12060775
- Fgfr2小鼠個體發育協方差模式研究
參考文獻：Martínez-Abadías N, Heuzé Y, Wang Y, Jabs EW, Aldridge K, Richtsmeier JT. FGF/FGFR signaling coordinates skull development by modulating magnitude of morphological integration: evidence from Apert syndrome mouse models. PLoS One. 2011;6(10):e26425. doi:10.1371/journal.pone.002642510.大腸桿菌感染肥胖小鼠腸道免疫研究 參考文獻：Cai D, Tian B, Liang S, et al. More Active Intestinal Immunity Developed by Obese Mice Than Non-Obese Mice After Challenged by Escherichia coli. Front Vet Sci. 2022;9:851226. Published 2022 Jun 3. doi:10.3389/fvets.2022.85122611.遺傳背景對腎病小鼠的影響研究參考文獻：Bufi R, Korstanje R. The impact of genetic background on mouse models of kidney disease. Kidney Int. 2022;102(1):38-44. doi:10.1016/j.kint.2022.03.02012.白細胞介素10缺乏加重雄性小創傷性腦損傷研究參考文獻：Gu Y, Dong Y, Wan J, Ren H, Koehler RC, Wang J. Interleukin-10 deficiency aggravates traumatic brain injury in male but not female mice. Exp Neurol. 2022;355:114125. doi:10.1016/j.expneurol.2022.11412513.NCSTN突變對小鼠毛囊成分的影響研究參考文獻：Shi TW, Cao W, Zhao QZ, Yu HX, Zhang SS, Hao YB. Effects of NCSTN Mutation on Hair Follicle Components in Mice [published online ahead of print, 2022 Jul 15]. Dermatology. 2022;1-12. doi:10.1159/00052552614.人和小鼠腎單位發育研究參考文獻：Schnell J, Achieng M, Lindström NO. Principles of human and mouse nephron development [published online ahead of print, 2022 Jul 22]. Nat Rev Nephrol. 2022;10.1038/s41581-022-00598-5. doi:10.1038/s41581-022-00598-515.大鼠食管吻合磁壓技術研究參考文獻：Zhang M, Shi A, Liu P, et al. Magnetic Compression Technique for Esophageal Anastomosis in Rats. J Surg Res. 2022;276:283-290. doi:10.1016/j.jss.2022.03.001
16. 肺動脈高壓大鼠心房收縮行為研究
參考文獻：Lookin O, Mukhlynina E, Protsenko Y. Contractile Behavior of Right Atrial Myocardium of Healthy Rats and Rats with the Experimental Model of Pulmonary Hypertension. Int J Mol Sci. 2022;23(8):4186. Published 2022 Apr 10. doi:10.3390/ijms2308418617.Vericiguat在大鼠和狗體內的藥代動力學和質量平衡分布研究 參考文獻：Janssen W, Schwarz T, Bütehorn U, et al. Pharmacokinetics and mass balance of vericiguat in rats and dogs and distribution in rats. Xenobiotica. 2022;52(5):453-462. doi:10.1080/00498254.2022.2082899
18. 光損傷白化大鼠視錐細胞研究
參考文獻：Benthal MC, McKeown AS, Kraft TW. Cone Photoreceptor Loss in Light-Damaged Albino Rats. Int J Mol Sci. 2022;23(7):3978. Published 2022 Apr 2. doi:10.3390/ijms23073978
1.人類前交叉韌帶斷裂自發動物模型參考文獻：Binversie EE, Walczak BE, Cone SG, Baker LA, Scerpella TA, Muir P. Canine ACL rupture: a spontaneous large animal model of human ACL rupture. BMC Musculoskelet Disord. 2022;23(1):116. Published 2022 Feb 5. doi:10.1186/s12891-021-04986-z2.n6-OHDA誘導新生大鼠模型參考文獻：Stauch CM, Fanburg-Smith JC, Walley KC, et al. Animal model detects early pathologic changes of Charcot neuropathic arthropathy. Ann Diagn Pathol. 2022;56:151878. doi:10.1016/j.anndiagpath.2021.1518783.B型胱氨酸尿癥FVB/NJcl小鼠模型 參考文獻：Sasaki H, Sasaki T, Hiura K, Watanabe M, Sasaki N. A mouse model of type B cystinuria due to spontaneous mutation in FVB/NJcl mice [published online ahead of print, 2022 Aug 21]. Urolithiasis. 2022;10.1007/s00240-022-01356-9. doi:10.1007/s00240-022-01356-9
4. 退行性脊柱側凸小鼠模型
參考文獻：Hu Z, Tang Z, Kiram A, et al. The Establishment of a Mouse Model for Degenerative Kyphoscoliosis Based on Senescence-Accelerated Mouse Prone 8. Oxid Med Cell Longev. 2022;2022:7378403. Published 2022 Jul 20. doi:10.1155/2022/7378403
5. 敗血癥免疫抑制小鼠模型
參考文獻：Wang N, Lu Y, Zheng J, Liu X. Of mice and men: Laboratory murine models for recapitulating the immunosuppression of human sepsis. Front Immunol. 2022;13:956448. Published 2022 Aug 5. doi:10.3389/fimmu.2022.9564486.肝實質損傷和再生小鼠模型 參考文獻：Du Y, Zhang W, Qiu H, et al. Mouse Models of Liver Parenchyma Injuries and Regeneration. Front Cell Dev Biol. 2022;10:903740. Published 2022 May 5. doi:10.3389/fcell.2022.9037407.牙周炎大鼠模型參考文獻：Gao J, Cai S, Wang Z, et al. The optimization of ligature/bone defect-induced periodontitis model in rats [published online ahead of print, 2022 Jun 3]. Odontology. 2022;10.1007/s10266-022-00715-7. doi:10.1007/s10266-022-00715-78.食管胃吻合口狹窄大鼠模型 參考文獻：Li N, Fei X, Li C, Zhao T, Jin H, Chen H. A Rat Model of Esophagogastric Anastomotic Stricture [published online ahead of print, 2022 May 23]. Eur Surg Res. 2022;10.1159/000525168. doi:10.1159/0005251689.新生大鼠神經轉移模型 參考文獻：Sporer ME, Aman M, Bergmeister KD, et al. Experimental nerve transfer model in the neonatal rat. Neural Regen Res. 2022;17(5):1088-1095. doi:10.4103/1673-5374.32485110.體積性肌肉損失大鼠模型參考文獻：Dolan CP, Dearth CL, Corona BT, Goldman SM. Retrospective characterization of a rat model of volumetric muscle loss. BMC Musculoskelet Disord. 2022;23(1):814. Published 2022 Aug 26. doi:10.1186/s12891-022-05760-511.前列腺癌大鼠模型 參考文獻：Bosland MC, Schlicht MJ, Horton L, McCormick DL. The MNU Plus Testosterone Rat Model of Prostate Carcinogenesis. Toxicol Pathol. 2022;50(4):478-496. doi:10.1177/01926233221096345
12. 慢性脊髓受壓大鼠模型
參考文獻：Miura M, Furuya T, Hashimoto M, et al. Differences in the expression of myelopathy in a rat model of chronic spinal cord compression [published online ahead of print, 2022 Aug 22]. J Spinal Cord Med. 2022;1-9. doi:10.1080/10790268.2022.2111048
13.小鼠尾動脈吻合模型
參考文獻：Wu XQ, Liu HR, Yu ZY, et al. A Super-Microsurgery Training Model: The Mouse Caudal Artery Anastomosis Model. Front Surg. 2022;9:841302. Published 2022 Apr 7. doi:10.3389/fsurg.2022.84130214.糖蛋白Ib-IX小鼠模型 參考文獻：Ware J. Murine models of glycoprotein Ib-IX. Platelets. 2022;33(6):811-816. doi:10.1080/09537104.2021.202211515.甲亢小鼠模型 參考文獻：Zhang M, Jiang W, Lu G, Wang R, Lv Z, Li D. Insight Into Mouse Models of Hyperthyroidism. Front Endocrinol (Lausanne). 2022;13:929750. Published 2022 Jun 22. doi:10.3389/fendo.2022.92975016.缺血性腦卒中食蟹猴模型 參考文獻：Ye J, Shang H, Du H, et al. An Optimal Animal Model of Ischemic Stroke Established by Digital Subtraction Angiography-Guided Autologous Thrombi in Cynomolgus Monkeys. Front Neurol. 2022;13:864954. Published 2022 Apr 25. doi:10.3389/fneur.2022.86495417.獼猴耳鳴動物模型 參考文獻：Rogenmoser L, Ku?mierek P, Archakov D, Rauschecker JP. The blinking eye as a window into tinnitus: A new animal model of tinnitus in the macaque. Hear Res. 2022;420:108517. doi:10.1016/j.heares.2022.10851718.應激性干眼癥非人靈長類動物模型 參考文獻：Gong L, Guan Y, Cho W, et al. A new non-human primate model of desiccating stress-induced dry eye disease. Sci Rep. 2022;12(1):7957. Published 2022 May 13. doi:10.1038/s41598-022-12009-719.自閉癥模型狨猴模型參考文獻：Nakagami A, Yasue M, Nakagaki K, Nakamura M, Kawai N, Ichinohe N. Reduced childhood social attention in autism model marmosets predicts impaired social skills and inflexible behavior in adulthood. Front Psychiatry. 2022;13:885433. Published 2022 Jul 25. doi:10.3389/fpsyt.2022.885433
20. 輻射誘發的小鼠顳下頜關節損傷模型
參考文獻：Zhang P, Yao L, Shan G, Chen Y. A model of radiation-induced temporomandibular joint damage in mice [published online ahead of print, 2022 Apr 27]. Int J Radiat Biol. 2022;1-10. doi:10.1080/09553002.2022.2069298
21. 原發性痛經小鼠模型
參考文獻：Hong F, He G, Zhang M, Yu B, Chai C. The Establishment of a Mouse Model of Recurrent Primary Dysmenorrhea. Int J Mol Sci. 2022;23(11):6128. Published 2022 May 30. doi:10.3390/ijms2311612822.唐氏綜合征聽力障礙小鼠模型 參考文獻：Chen GD, Li L, McCall A, et al. Hearing impairment in murine model of Down syndrome. Front Genet. 2022;13:936128. Published 2022 Aug 4. doi:10.3389/fgene.2022.936128 圖片均來源于網絡
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